Negin Tafazzoli Mohammadzadeh moved to the U.S. in the fall of 1983. She graduated cum laude from Georgia State University with a degree in finance and subsequently worked as a Loan Officer at Union Bank.

Her involvement with MAHAK and International Society for Children with Cancer (ISCC) started in the spring of 2007. She has served ISCC as the volunteer president of the Board of Directors since 2008. ISCC is a non-profit organization established with the purpose of and commitment to globally increase access to treatment for underprivileged children with cancer and support their families during the healing process. To date, it has provided annual grants to 16 NGOs in 12 countries.

She has also been an integral part of the Adult Gift of Life program, which arranges for indigent patients from developing countries to be brought to Southern California for life-saving heart surgeries, free of charge. She served as the president of the Rotary Club of Conejo Vallery Centennial, a chapter of Rotary International, in 2006 and 2007 and is currently an honorary member of Conejo Valley Rotary Club.