Diffuse cerebral vasoconstriction (Call-Fleming syndrome) and stroke associated with antidepressants

Neurology. 2006 Jul 11;67(1):159-60.

Jafarimojarrad E, Noskin O, Libman RB, Nelson JL.

Authors information:
Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY
11040, USA.

Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral
arteries manifested by a \"thunderclap\" headache and focal neurologic symptoms.
Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients with history of antidepressant use. Although the association is hypothetical, the authors suggest consideration of Call-Fleming syndrome in patients presenting with headache, focal deficits, and evidence of cerebral ischemia during antidepressant use.